In 2004, Lathan starred on Broadway in A Raisin in the Sun with Sean Combs, Audra McDonald, and Phylicia Rashad. Lathan received a Tony Award nomination for Best Performance by a Featured Actress for her portrayal of Beneatha Younger. Several years later, Lathan reprised the role in a critically acclaimed ABC Network production of A Raisin in the Sun.
Lathan subsequently starred in several major Hollywood films, including Alien vs. Predator, which was Lathan's biggest role to date. Alien vs. Predator was a major success grossing over $171 million worldwide. Out of Time was also an important role for Lathan as she played the plot-twist antagonist, sharing the screen with protagonist Denzel Washington.
In 2006, Lathan co-starred with Simon Baker in Something New, a romantic comedy about an interracial relationship. Lathan appeared in a recurring role as Michelle Landau in another interracial relationship as the much younger wife of a Texas businessman (Larry Hagman) during the fourth season of the television series, Nip/Tuck.
Lathan played Andrea in Tyler Perry's The Family That Preys. The film also features Alfre Woodard and Kathy Bates; it was released in the U.S. on September 12, 2008.
In 2009, Lathan co-starred with Matthew Broderick in the drama Wonderful World. She also began voicing the character Donna Tubbs on The Cleveland Show.
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